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Strain-specific Lyme disease immunity lasts for years, Penn research finds

(University of Pennsylvania) A new study led by researchers from the University of Pennsylvania shows that humans appear to develop immunity against specific strains of the Lyme disease that can last six to nine years. (Source: EurekAlert! - Infectious and Emerging Diseases)

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Exposure to Borrelia burgdorferi and Other Tick-Borne Pathogens in Gettysburg National Military Park, South-Central Pennsylvania, 2009

Vector-Borne and Zoonotic Diseases , Vol. 0, No. 0. (Source: Vector-Borne and Zoonotic Diseases)

[CXCL13: a biomarker for acute Lyme neuroborreliosis : Investigation of the predictive value in the clinical routine.]

CONCLUSIONS: The biomarker CXCL13 has a higher sensitivity (100 % vs. 87 %) with a specificity (99 %) comparable with the established diagnostic markers for LNB, e.g. CSF pleocytosis and Borrelia-AI in the investigated patient population. The negative predictive value of CXCL13 is 100 %. Therefore, a normal CXCL13 level virtually excludes LNB. In the clinical routine CXCL13 is a valuable and practical diagnostic marker for LNB and can even detect an acute LNB in patients without CSF pleocytosis. PMID: 24682168 [PubMed - as supplied by publisher] (Source: Der Nervenarzt)

Oral doxycycline for Lyme neuroborreliosis with symptoms of encephalitis, myelitis, vasculitis or intracranial hypertension

ConclusionTreatment with oral doxycycline resulted in a similar decrease in CSF mononuclear cell counts in patients with Lyme neuroborreliosis with CNS symptoms compared with patients with Lyme neuroborreliosis with PNS symptoms. The results indicate that oral doxycycline is an effective treatment for Lyme neuroborreliosis irrespective of the severity of symptoms. (Source: European Journal of Neurology)

A82: Lyme Arthritis: an Emerging Clinical Problem in Nova Scotia, Canada

Conclusion:Increasing numbers of children with Lyme arthritis are being seen in the pediatric rheumatology clinic in Nova Scotia. LD was not considered as a diagnosis in the majority of cases by the referring physician. A quarter of patients also had a history of unrecognized neurologic manifestations of LD. In keeping with published North American reports, most patients had an excellent outcome however a proportion continued to have arthritis and disability following antibiotic therapy. (Source: Arthritis and Rheumatism)

Mice are reservoirs for tick-borne pathogens, amplify risk of Lyme disease and other tick-borne ailments

People living in northern and central parts of the U.S. are more likely to contract Lyme disease and other tick-borne ailments when white-footed mice are abundant. Mice are effective at transferring disease-causing pathogens to feeding ticks. And, according to an in-press paper in the journal Ecology, these "super hosts" appear indifferent to larval tick infestations. (Source: Health News from Medical News Today)

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